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Because B12 shots are administered intramuscularly, they bypass the digestive system, allowing the body to absorb a much larger amount of B12 that would otherwise be lost during digestion

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A post-hoc analysis of this trial revealed that tirzepatide users experienced an amelioration of the atherogenic lipoprotein profile with reduction in large triglyceride rich lipid particles, small low-density lipoprotein particles (LDLP) and apolipoprotein B, consistent with the significant improvement of insulin sensitivity

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Most reported side effects are mild and often resolve without intervention